PAX5

PAX5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1K78, 1MDM
Dynodwyr
Cyfenwau	PAX5, ALL3, BSAP, paired box 5, PAX-5
Dynodwyr allanol	OMIM: 167414 HomoloGene: 56419 GeneCards: PAX5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • fibrillar center • cytosol • intracellular membrane-bounded organelle • nucleoplasm Prosesau biolegol • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • lateral ventricle development • GO:0010260 heneiddio • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • nervous system development • multicellular organism development • adult behavior • humoral immune response • spermatogenesis • negative regulation of histone H3-K9 methylation • cerebral cortex development • animal organ morphogenesis • skeletal muscle cell differentiation • embryonic cranial skeleton morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • regulation of B cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5079	n/a
Ensembl	ENSG00000196092	n/a
UniProt	Q02548	n/a
RefSeq (mRNA)	NM_001280547 NM_001280548 NM_001280549 NM_001280550 NM_001280551 NM_001280552 NM_001280553 NM_001280554 NM_001280555 NM_001280556 NM_016734	n/a
RefSeq (protein)	NP_001267476 NP_001267477 NP_001267478 NP_001267479 NP_001267480 NP_001267481 NP_001267482 NP_001267483 NP_001267484 NP_001267485 NP_057953 NP_001267480.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAX5 yw PAX5 a elwir hefyd yn Paired box 5 a Paired box protein Pax-5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAX5.

• ALL3
• BSAP

Llyfryddiaeth

• "[Significance of PAX5 deletion in childhood B-lineage acute lymphoblastic leukemia without reproducible chromosomal abnormalities]. ". Zhongguo Dang Dai Er Ke Za Zhi. 2016. PMID 27097569.
• "PAX5 promotes pre-B cell proliferation by regulating the expression of pre-B cell receptor and its downstream signaling. ". Mol Immunol. 2016. PMID 27016671.
• "Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line. ". Biomed Res Int. 2017. PMID 28316978.
• "Ph-like acute lymphoblastic leukemia with a novel PAX5-KIDINS220 fusion transcript. ". Genes Chromosomes Cancer. 2017. PMID 27870151.
• "Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination.". Nat Immunol. 2016. PMID 27525369.