LRRC4

LRRC4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DL9, 3ZYI
Dynodwyr
Cyfenwau	LRRC4, NGL-2, NAG14, leucine rich repeat containing 4
Dynodwyr allanol	OMIM: 610486 HomoloGene: 36403 GeneCards: LRRC4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase inhibitor activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • integral component of membrane • neuron spine • cell junction • postsynaptic membrane • dendritic spine • Cellbilen • synapse • excitatory synapse • bilen • Schaffer collateral - CA1 synapse • glutamatergic synapse • integral component of postsynaptic density membrane Prosesau biolegol • synapse organization • postsynaptic density protein 95 clustering • GO:1904739 regulation of synapse organization • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • negative regulation of receptor signaling pathway via JAK-STAT • modulation of chemical synaptic transmission • synaptic membrane adhesion • excitatory synapse assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	64101	n/a
Ensembl	ENSG00000128594	n/a
UniProt	Q9HBW1	n/a
RefSeq (mRNA)	NM_022143	n/a
RefSeq (protein)	NP_071426	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LRRC4 yw LRRC4 a elwir hefyd yn Leucine rich repeat containing 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LRRC4.

• NAG14
• NGL-2

Llyfryddiaeth

• "LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression. ". J Neurooncol. 2006. PMID 16941076.
• "Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array. ". Acta Biochim Biophys Sin (Shanghai). 2005. PMID 16215635.
• "LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population. ". Med Oncol. 2014. PMID 24563334.
• "Promoter hypermethylation-mediated inactivation of LRRC4 in gliomas. ". BMC Mol Biol. 2008. PMID 18976507.
• "LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses.". J Cell Physiol. 2008. PMID 17541939.