IL10 Dynodwyr Cyfenwau IL10 Dynodwyr allanol OMIM: 124092 HomoloGene: 478 GeneCards: IL10 Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • growth factor activity • cytokine activity • interleukin-10 receptor binding • protein dimerization activity Cydrannau o'r gell • extracellular region • extracellular space Prosesau biolegol • negative regulation of chronic inflammatory response to antigenic stimulus • positive regulation of MHC class II biosynthetic process • negative regulation of endothelial cell apoptotic process • hemopoiesis • negative regulation of interferon-gamma production • regulation of sensory perception of pain • positive regulation of B cell apoptotic process • negative regulation of chemokine (C-C motif) ligand 5 production • response to inactivity • negative regulation of cytokine activity • negative regulation of interleukin-1 production • cellular response to hepatocyte growth factor stimulus • cellular response to estradiol stimulus • negative regulation of interleukin-6 production • GO:0010260 heneiddio • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • GO:0002719 negative regulation of cytokine production involved in immune response • response to glucocorticoid • cytoplasmic sequestering of NF-kappaB • negative regulation of interleukin-18 production • negative regulation of MHC class II biosynthetic process • response to activity • response to organic substance • response to carbon monoxide • leukocyte chemotaxis • type 2 immune response • negative regulation of myeloid dendritic cell activation • response to insulin • negative regulation of interleukin-8 production • response to lipopolysaccharide • B cell proliferation • negative regulation of T cell proliferation • negative regulation of nitric oxide biosynthetic process • branching involved in labyrinthine layer morphogenesis • defense response to bacterium • regulation of complement-dependent cytotoxicity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of gene expression • B cell differentiation • regulation of isotype switching • negative regulation of tumor necrosis factor production • negative regulation of membrane protein ectodomain proteolysis • inflammatory response • cellular response to lipopolysaccharide • negative regulation of B cell proliferation • negative regulation of inflammatory response • GO:0032697 negative regulation of cytokine production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of interleukin-12 production • defense response to protozoan • negative regulation of sensory perception of pain • positive regulation of macrophage activation • liver regeneration • GO:1904739 regulation of synapse organization • positive regulation of endothelial cell proliferation • negative regulation of cell population proliferation • negative regulation of heterotypic cell-cell adhesion • positive regulation of heterotypic cell-cell adhesion • positive regulation of cell cycle • negative regulation of mitotic cell cycle • endothelial cell apoptotic process • regulation of response to wounding • negative regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • interleukin-12-mediated signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of autophagy • cytokine-mediated signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of hydrogen peroxide-induced neuron death • positive regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn IL10 yw IL10 a elwir hefyd yn Interleukin 10 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q32.1.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL10.
CSIF
TGIF
GVHDS
IL-10
IL10A
"Association of interleukin-10 gene single nucleotide polymorphisms with susceptibility to systemic lupus erythematosus in a Chinese population. ". Gene . 2018. PMID 29199038 . "Association of Systemic Inflammatory and Anti-inflammatory Responses with Adverse Outcomes in Acute Pancreatitis: Preliminary Results of an Ongoing Study. ". Dig Dis Sci . 2017. PMID 29080144 . "Interleukin-10-regulated tumour tolerance in non-small cell lung cancer. ". Br J Cancer . 2017. PMID 29016555 . "IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer. ". Cancer Res . 2017. PMID 28993412 . "Alzheimer's disease and cytokine IL-10 gene polymorphisms: is there an association?". Arq Neuropsiquiatr. 2017. PMID 28977146 . 
