JUN

Protein sy'n cael ei godio yn y corff dynol gan y genyn JUN yw JUN a elwir hefyd yn Jun proto-oncogene, AP-1 transcription factor subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p32.1.

JUN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS
Dynodwyr
Cyfenwau	JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit, p39, cJUN
Dynodwyr allanol	OMIM: 165160 HomoloGene: 1679 GeneCards: JUN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • cAMP response element binding • R-SMAD binding • HMG box domain binding • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • enzyme binding • chromatin binding • GO:0001948, GO:0016582 protein binding • double-stranded DNA binding • DNA binding • sequence-specific DNA binding • GO:0001105 transcription coactivator activity • identical protein binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA binding • protein homodimerization activity • protein heterodimerization activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • GO:0000975 transcription cis-regulatory region binding Cydrannau o'r gell • cytosol • transcription repressor complex • cnewyllyn cell • nuclear chromosome • nucleoplasm • transcription regulator complex • transcription factor AP-1 complex Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • negative regulation of DNA binding • outflow tract morphogenesis • transcription by RNA polymerase II • learning • monocyte differentiation • response to organic substance • leading edge cell differentiation • Fc-epsilon receptor signaling pathway • positive regulation of neuron apoptotic process • cellular response to hormone stimulus • regulation of DNA-binding transcription factor activity • Rhythm circadaidd • angiogenesis • positive regulation of ERK1 and ERK2 cascade • Ras protein signal transduction • transforming growth factor beta receptor signaling pathway • negative regulation of cell population proliferation • response to muscle stretch • cellular response to calcium ion • response to cytokine • GO:0009373 regulation of transcription, DNA-templated • SMAD protein signal transduction • axon regeneration • positive regulation of fibroblast proliferation • response to mechanical stimulus • positive regulation of epithelial cell migration • positive regulation of DNA-templated transcription, initiation • transcription, DNA-templated • positive regulation of cell differentiation • positive regulation of monocyte differentiation • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of protein autophosphorylation • membrane depolarization • negative regulation of apoptotic process • eyelid development in camera-type eye • microglial cell activation • positive regulation of DNA replication • response to lipopolysaccharide • response to radiation • response to cAMP • GO:0045996 negative regulation of transcription, DNA-templated • response to hydrogen peroxide • positive regulation of smooth muscle cell proliferation • positive regulation of endothelial cell proliferation • GO:1904578 response to organic cyclic compound • GO:0010260 heneiddio • regulation of cell cycle • regulation of cell population proliferation • positive regulation of cell population proliferation • liver development • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • cellular response to potassium ion starvation • GO:0006928 cellular process • release of cytochrome c from mitochondria • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • GO:0072353 cellular response to reactive oxygen species • positive regulation of apoptotic process • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cellular response to cadmium ion • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of vascular associated smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3725	n/a
Ensembl	ENSG00000177606	n/a
UniProt	P05412	n/a
RefSeq (mRNA)	NM_002228	n/a
RefSeq (protein)	NP_002219	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn JUN.

• AP1
• p39
• AP-1
• c-Jun

Llyfryddiaeth

• "Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma. ". J Pineal Res. 2017. PMID 28178378.
• "JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia. ". Leukemia. 2017. PMID 27840425.
• "Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer. ". Ann Oncol. 2016. PMID 27022066.
• "Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance. ". Mol Cancer Res. 2016. PMID 26965145.
• "Activation of c-Jun predicts a poor response to sorafenib in hepatocellular carcinoma: Preliminary Clinical Evidence.". Sci Rep. 2016. PMID 26964667.