File:MicroRNAs biogenesis.jpg

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English: Overview of the miRNAs biogenesis. In the canonical pathway in the nucleus, pri-miRNAs are cleaved into pre-miRNAs by Drosha. Pre-miRNAs are exported to the cytoplasm by exportin 5. In the cytoplasm, pre-miRNAs are cleaved into small dsRNAs by Dicer. Then, RISC mediates the recognition of the mRNA to be targeted. In the non-canonical pathway (Mirtron), Drosha cleavage is substituted with splicing. pri-miRNAs (pre-mRNAs) are processed to pre-miRNAs by the spliceosome machinery and debranching enzyme to generate double-stranded loop structures like the regular miRNAs. Subsequently, the RNA product of splicing adopts a pre-miRNA like form, and transferred to the cytoplasm by exportin 5 to continue with the canonical pathway. For more details please refer to the text.
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Author Kioomars743

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current10:37, 13 July 2019Thumbnail for version as of 10:37, 13 July 20192,362 × 2,362 (1.43 MB)Kioomars743 (talk | contribs)Cross-wiki upload from commons.wikimedia.org

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