Genome sequencing efforts mean that we now have extensive data from a wide range of organisms to ... more Genome sequencing efforts mean that we now have extensive data from a wide range of organisms to study. Understanding the differing natures of the biology of these organisms is an important aim of genome analysis. We are interested in signals that affect translation of mRNAs. Some signals in the mRNA influence how efficiently it is translated into protein. Previous studies have indicated that many important signals are located around the initiation and termination codons. We have developed tools described here to extract the relevant sequence regions from GenBank ® . To create databases organised by species, or higher taxonomic groupings (eg planta), a program was developed to dynamically view and edit the taxonomy database. Data from relevant species were then extracted using our Genbank feature table parser. We analysed all available sequences, particularly those from complete genomes. Patterns were then identified using information theory. The software is available from http://transterm.otago.ac.nz. Patterns around the initiation codons for most of the organisms fall into two groups, containing the previously known Shine-Dalgarno and Kozaks efficiency signals. However, we have identified several organisms that appear to utilise novel systems. Our analysis indicates that some organisms with extremely high GC% genomes do not have a strong dependence on base pairing ribosome binding sites, as the complementary sequence is absent from many genes.
The Chinese political theory tradition grew out of a debate between several powerful schools and ... more The Chinese political theory tradition grew out of a debate between several powerful schools and is in some ways more deeply and intrinsically pluralistic than thinking in the west.Keywords:communitarianism;just war;justicecommunitarianism;just war;justice
... Clinical signs observed in bats have been weak-ness and paralysis (J. Barrett, P. Young, H. F... more ... Clinical signs observed in bats have been weak-ness and paralysis (J. Barrett, P. Young, H. Field, B. Rodwell, G. Smith, and P. Hooper, 48th Annu. ... The approach was to sur-vey a range of animal species, with pteropid fruit bats as the highest pri-ority (MY Johara, H. Field, AR ...
BACKGROUNDDyspepsia drug costs account for nearly 0.5% of the National Health Service budget. We ... more BACKGROUNDDyspepsia drug costs account for nearly 0.5% of the National Health Service budget. We hypothesised that improved management of dyspepsia would lead to reduced drug costs.AIMTo determine whether a multifaceted educational strategy for general practitioners aimed at improving quality of dyspepsia management can control dyspepsia costs without increasing demand for endoscopy.METHODSA multifaceted educational intervention was delivered to general practitioners in
The Business School at the University of Hertfordshire (UH) employs approximately 150 academic st... more The Business School at the University of Hertfordshire (UH) employs approximately 150 academic staff in a state-of-the-art environment located in Hatfield Business Park. It offers 17 undergraduate degree programmes, 21 postgraduate programmes and there are about 80 research students, mostly working at doctoral level. Business School staff are active in research in numerous areas, including complexity theory, institutional economics, economic modelling, efficiency measurement the creative industries, employment studies, finance, accounting, statistical methods and management science. The University of Hertfordshire has been recognised as the exemplar of a business-facing university. It is one of the region's largest employers with over 2,700 staff and a turnover of £205 m. In the 2008 UK Research Assessment Exercise it was given the highest rank for research quality among the post-1992 universities.
... tov où voaoCvia xoùSèv т)§1ХГ|>сота. 38) The imagery suggests a plague here as well: cf. S... more ... tov où voaoCvia xoùSèv т)§1ХГ|>сота. 38) The imagery suggests a plague here as well: cf. SPind. Pyth. 3.66b (2.73 Drachmann); David Young, Three Odes of Pindar (Leiden 1968), 39 with n. 1. For fire-imagery used of plague, cf. Soph. ОТ 27, 166; Thuc. 2.49. ...
Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching exasbng data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information If it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.
New Hampshire and Vermont currently have two rabies epizootics occurring in raccoon and fox popul... more New Hampshire and Vermont currently have two rabies epizootics occurring in raccoon and fox populations. These are continuations of the established raccoon strain which has been migrating northward from the mid-Atlantic and the fox strain which is migrating south and eastward from Canada and New York. These started in the early 1990s, and the wild animal cases have increased from 0 to 1 case per year in Vermont in the late 1980s to 179 in 1995, and from 0 to 4 cases in New Hampshire to 152 in 1995. Since 1992 there has been a slight increase in domestic animal cases, but no human cases have been reported. The cost of prophylaxis and animal testing has greatly increased, including one episode where 665 persons were exposed to a rabid kitten and underwent postexposure prophylaxis at an estimated cost of $1.5 million. This paper gives epidemiologic data for the two states and reviews the current literature to discuss history, clinical features, testing, postexposure prophylaxis, and treatment of rabies.
Background: There is evidence in breast, colorectal and prostate cancer that patients who use bet... more Background: There is evidence in breast, colorectal and prostate cancer that patients who use beta-blocker (BB) medication have better cancer outcomes. There is some evidence of similar benefits in ovarian tumours. We investigated whether BB use was associated with improved survival within Irish ovarian cancer patients. Method: Women diagnosed with invasive ovarian cancer (ICD code: C56) between 2001–2011 were identified from the National Cancer Registry Ireland. Those with continuous eligibility for a (means-tested) medical card in the year immediately prior to diagnosis were identified and linked to community prescription records. Any BB exposure (WHO ATC: C07) in the year prior to diagnosis was determined. Associations between exposure and ovarian cause-specific survival (OvCSS) and other causes until follow-up 31/12/2012 was estimated using Cox regression adjusted for: age, smoking, marital status, diagnosis year, urban/rural residence,deprivation, stage, grade, and surgery at diagn...
Background: There is evidence in breast, colorectal and prostate cancer that patients who use sta... more Background: There is evidence in breast, colorectal and prostate cancer that patients who use statins have better cancer outcomes. There is biological evidence of similar benefits in ovarian tumour cells. We investigated whether stain use was associated with survival in ovarian cancer patients in Ireland. Methods: Women diagnosed with invasive ovarian cancer (C56) between 2001-2011 were identified from the National Cancer Registry. Those with at least one year medical card history (means tested) pre-diagnosis were identified and linked to community prescription records. Any statin use (ATC code: C10AA,C10B) in the year prior to diagnosis was determined. Association between statin use and cause-specific survival (end of follow-up: 31/12/2012) was estimated using Cox regression (adjusted for: age, smoking, marital status, year of diagnosis, urban/rural, local area deprivation, stage, grade, surgery at diagnosis). Secondary analysis accounting for competing risk was conducted. Results:...
Genome sequencing efforts mean that we now have extensive data from a wide range of organisms to ... more Genome sequencing efforts mean that we now have extensive data from a wide range of organisms to study. Understanding the differing natures of the biology of these organisms is an important aim of genome analysis. We are interested in signals that affect translation of mRNAs. Some signals in the mRNA influence how efficiently it is translated into protein. Previous studies have indicated that many important signals are located around the initiation and termination codons. We have developed tools described here to extract the relevant sequence regions from GenBank ® . To create databases organised by species, or higher taxonomic groupings (eg planta), a program was developed to dynamically view and edit the taxonomy database. Data from relevant species were then extracted using our Genbank feature table parser. We analysed all available sequences, particularly those from complete genomes. Patterns were then identified using information theory. The software is available from http://transterm.otago.ac.nz. Patterns around the initiation codons for most of the organisms fall into two groups, containing the previously known Shine-Dalgarno and Kozaks efficiency signals. However, we have identified several organisms that appear to utilise novel systems. Our analysis indicates that some organisms with extremely high GC% genomes do not have a strong dependence on base pairing ribosome binding sites, as the complementary sequence is absent from many genes.
The Chinese political theory tradition grew out of a debate between several powerful schools and ... more The Chinese political theory tradition grew out of a debate between several powerful schools and is in some ways more deeply and intrinsically pluralistic than thinking in the west.Keywords:communitarianism;just war;justicecommunitarianism;just war;justice
... Clinical signs observed in bats have been weak-ness and paralysis (J. Barrett, P. Young, H. F... more ... Clinical signs observed in bats have been weak-ness and paralysis (J. Barrett, P. Young, H. Field, B. Rodwell, G. Smith, and P. Hooper, 48th Annu. ... The approach was to sur-vey a range of animal species, with pteropid fruit bats as the highest pri-ority (MY Johara, H. Field, AR ...
BACKGROUNDDyspepsia drug costs account for nearly 0.5% of the National Health Service budget. We ... more BACKGROUNDDyspepsia drug costs account for nearly 0.5% of the National Health Service budget. We hypothesised that improved management of dyspepsia would lead to reduced drug costs.AIMTo determine whether a multifaceted educational strategy for general practitioners aimed at improving quality of dyspepsia management can control dyspepsia costs without increasing demand for endoscopy.METHODSA multifaceted educational intervention was delivered to general practitioners in
The Business School at the University of Hertfordshire (UH) employs approximately 150 academic st... more The Business School at the University of Hertfordshire (UH) employs approximately 150 academic staff in a state-of-the-art environment located in Hatfield Business Park. It offers 17 undergraduate degree programmes, 21 postgraduate programmes and there are about 80 research students, mostly working at doctoral level. Business School staff are active in research in numerous areas, including complexity theory, institutional economics, economic modelling, efficiency measurement the creative industries, employment studies, finance, accounting, statistical methods and management science. The University of Hertfordshire has been recognised as the exemplar of a business-facing university. It is one of the region's largest employers with over 2,700 staff and a turnover of £205 m. In the 2008 UK Research Assessment Exercise it was given the highest rank for research quality among the post-1992 universities.
... tov où voaoCvia xoùSèv т)§1ХГ|>сота. 38) The imagery suggests a plague here as well: cf. S... more ... tov où voaoCvia xoùSèv т)§1ХГ|>сота. 38) The imagery suggests a plague here as well: cf. SPind. Pyth. 3.66b (2.73 Drachmann); David Young, Three Odes of Pindar (Leiden 1968), 39 with n. 1. For fire-imagery used of plague, cf. Soph. ОТ 27, 166; Thuc. 2.49. ...
Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching exasbng data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information If it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.
New Hampshire and Vermont currently have two rabies epizootics occurring in raccoon and fox popul... more New Hampshire and Vermont currently have two rabies epizootics occurring in raccoon and fox populations. These are continuations of the established raccoon strain which has been migrating northward from the mid-Atlantic and the fox strain which is migrating south and eastward from Canada and New York. These started in the early 1990s, and the wild animal cases have increased from 0 to 1 case per year in Vermont in the late 1980s to 179 in 1995, and from 0 to 4 cases in New Hampshire to 152 in 1995. Since 1992 there has been a slight increase in domestic animal cases, but no human cases have been reported. The cost of prophylaxis and animal testing has greatly increased, including one episode where 665 persons were exposed to a rabid kitten and underwent postexposure prophylaxis at an estimated cost of $1.5 million. This paper gives epidemiologic data for the two states and reviews the current literature to discuss history, clinical features, testing, postexposure prophylaxis, and treatment of rabies.
Background: There is evidence in breast, colorectal and prostate cancer that patients who use bet... more Background: There is evidence in breast, colorectal and prostate cancer that patients who use beta-blocker (BB) medication have better cancer outcomes. There is some evidence of similar benefits in ovarian tumours. We investigated whether BB use was associated with improved survival within Irish ovarian cancer patients. Method: Women diagnosed with invasive ovarian cancer (ICD code: C56) between 2001–2011 were identified from the National Cancer Registry Ireland. Those with continuous eligibility for a (means-tested) medical card in the year immediately prior to diagnosis were identified and linked to community prescription records. Any BB exposure (WHO ATC: C07) in the year prior to diagnosis was determined. Associations between exposure and ovarian cause-specific survival (OvCSS) and other causes until follow-up 31/12/2012 was estimated using Cox regression adjusted for: age, smoking, marital status, diagnosis year, urban/rural residence,deprivation, stage, grade, and surgery at diagn...
Background: There is evidence in breast, colorectal and prostate cancer that patients who use sta... more Background: There is evidence in breast, colorectal and prostate cancer that patients who use statins have better cancer outcomes. There is biological evidence of similar benefits in ovarian tumour cells. We investigated whether stain use was associated with survival in ovarian cancer patients in Ireland. Methods: Women diagnosed with invasive ovarian cancer (C56) between 2001-2011 were identified from the National Cancer Registry. Those with at least one year medical card history (means tested) pre-diagnosis were identified and linked to community prescription records. Any statin use (ATC code: C10AA,C10B) in the year prior to diagnosis was determined. Association between statin use and cause-specific survival (end of follow-up: 31/12/2012) was estimated using Cox regression (adjusted for: age, smoking, marital status, year of diagnosis, urban/rural, local area deprivation, stage, grade, surgery at diagnosis). Secondary analysis accounting for competing risk was conducted. Results:...
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