Papers by sara-joan pinto
Current problems in cardiology, Apr 1, 2024
Nederlands Tijdschrift voor Diabetologie, 2017
SamenvattingNederlandse Vereniging voor Diabetes Onderzoek (NVDO) Nederlandse Associatie voor de ... more SamenvattingNederlandse Vereniging voor Diabetes Onderzoek (NVDO) Nederlandse Associatie voor de Studie van Obesitas (NASO) Netherlands Diabetes Epidemiology Study Group (NDESG) Psychosocial Aspects of Diabetes (PSAD) Study Group Nederlandse Vereniging voor Neurovasculaire Complicaties van Diabetes (NVCD)30 November & 1 December 2017 Hotel de Bilderberg, Oosterbeek
Nephrology Dialysis Transplantation, 2003
Annals of Internal Medicine, 2001
TO THE EDITOR: Dr. Cassel writes in support of geriatric medicine (1), which has always been subs... more TO THE EDITOR: Dr. Cassel writes in support of geriatric medicine (1), which has always been subsumed as a major aspect of internal medicine. She maintains that “geriatricians . . . must have substantial knowledge of . . . psychiatry, rehabilitation, ophthalmology, audiology, gynecology, urology, orthopedics” and many other areas. I think her patients would best be served by referral to appropriate specialists in those fields. No evidence is provided that the elderly are better treated by physicians with geriatric training. The conditions Dr. Cassel considers to be “geriatric,” such as congestive heart failure, osteoarthritis, and urinary incontinence, are not restricted to any age group. Nor are preventive medicine, early diagnosis of disease, and awareness of the advantages of shorter hospitalization specifically geriatric subjects. In brief, I find no reason to expect better medical care in my senior state from a geriatrician than from a competent internist.
Take-down policy If you believe that this document breaches copyright please contact us providing... more Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Journal of Medical Virology, 2021
The role of antihypertensives, especially Renin–Angiotensin–Aldosterone System inhibitors, is sti... more The role of antihypertensives, especially Renin–Angiotensin–Aldosterone System inhibitors, is still debatable in COVID‐19‐related severity and outcome. Therefore, we search for a more global analysis of antihypertensive medication in relation to SAS‐CoV‐2 severity using prescription data worldwide. The association between the percentage use of different types of antihypertensive medications and mortality rates due to a SARS‐CoV‐2 infection during the first 3 weeks of the pandemic was analyzed using random effects linear regression models for 30 countries worldwide. Higher percentages of prescribed angiotensin receptor blockers (ARBs) (β, 95% confidence interval [CI]; −0.02 [−0.04 to −0.0012]; p = .042) and calcium channel blockers (CCBs) (β, 95% CI; −0.023 [−0.05 to −0.0028]; p = .0304) were associated with a lower first 3‐week SARS‐CoV‐2‐related death rate, whereas a higher percentage of prescribed angiotensin‐converting enzyme inhibitors (ACEis) (β, 95% CI; 0.03 [0.0061–0.05]; p =...
Nederlands Tijdschrift voor Geneeskunde, 2020
Annual Review of Medicine, 2019
Cardiometabolic disease (CMD), such as type 2 diabetes mellitus and cardiovascular disease, contr... more Cardiometabolic disease (CMD), such as type 2 diabetes mellitus and cardiovascular disease, contributes significantly to morbidity and mortality on a global scale. The gut microbiota has emerged as a potential target to beneficially modulate CMD risk, possibly via dietary interventions. Dietary interventions have been shown to considerably alter gut microbiota composition and function. Moreover, several diet-derived microbial metabolites are able to modulate human metabolism and thereby alter CMD risk. Dietary interventions that affect gut microbiota composition and function are therefore a promising, novel, and cost-efficient method to reduce CMD risk. Studies suggest that fermentable carbohydrates can beneficially alter gut microbiota composition and function, whereas high animal protein and high fat intake negatively impact gut microbiota function and composition. This review focuses on the role of macronutrients (i.e., carbohydrate, protein, and fat) and dietary patterns (e.g., ...
Nature Medicine, 2018
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Atherosclerosis, 2016
There is discussion about incorporating a family history (FamHis) of premature coronary artery di... more There is discussion about incorporating a family history (FamHis) of premature coronary artery disease (CAD) in risk score algorithms. However, FamHis provides information on individual risk. Coronary artery calcification score (CACS) is a metric of atherosclerosis that may determine the individual risk within families at high risk of premature CAD. In asymptomatic individuals (n = 704), we assessed the association between FamHis of CAD and elevated CACS. To assess the predictive value of CACS in individuals with a FamHis of CAD, we performed a post-hoc analysis on the St. Francis Heart Study (n = 834). We assessed, in a case control design, the risk of future CAD in individuals with a FamHis of CAD and either CACS >80th percentile or no CACS at all. Individuals with a FamHis for CAD had an increased risk for elevated CACS (adjusted odds ratio (OR) 2.23 (95% CI 1.48-3.36); p < 0.05), compared to those without a FamHis. In the prospective study (3.5 years follow-up), the event rate equally low in those with a positive FamHis and a negative FamHis (0% vs. 1%), if they had a CAC of 0. However, in those with CACS >80(th) percentile, a FamHis of CAD doubled the CAD event rate (positive FamHis 12.5% vs. negative FamHis 6.8%; adjusted HR 2.08 (95% CI 1.09-3.87; p < 0.05). CAC scoring leads to risk discrimination among those with a positive FamHis for premature CAD. These results support testing CAC score in asymptomatic individuals with a positive FamHis to identify a high risk population.
Atherosclerosis Supplements, 2009
Hipertensión y Riesgo Vascular, 2001
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jan 28, 2015
Circulating microRNAs (miRNAs) have been reported as biomarkers for disease diagnosis. RT-qPCR is... more Circulating microRNAs (miRNAs) have been reported as biomarkers for disease diagnosis. RT-qPCR is most commonly used to detect miRNAs; however, no consensus on the most appropriate method for data normalization exists. Via a standardized selection method, we aimed to determine separate miRNA normalization panels for RT-qPCR measurements on whole blood, platelets, and serum. Candidate miRNAs were selected from studies describing circulating miRNA microarray data in the Gene Expression Omnibus or ArrayExpress. miRNA expression data of healthy controls were retrieved from each study. For each sample type, we selected those miRNAs that were least variable and sufficiently highly expressed in multiple microarray experiments, performed on at least 2 different platforms. Stability of the candidate miRNAs was assessed using NormFinder and geNorm algorithms in a RT-qPCR cohort of 10 patients with coronary artery disease and 10 healthy controls. We selected miRNA normalization panels for RT-q...
Atherosclerosis Supplements, 2011
Aims: to assess the impact of low cholesterol value in midlife on survival and health-related qua... more Aims: to assess the impact of low cholesterol value in midlife on survival and health-related quality of life (HRQoL) in old age. Methods: A total of 3277 healthy, middle-aged businessmen (born between 1919 and 1934) without chronic diseases at baseline in 1964-1973 were included in the analyses. They were divided into seven groups according to their baseline cholesterol value, the lowest value being <4 mmol/L and highest >9 mmol/L. The men were followed up for up to 46 years (until the end of January 2010), and mortality was ascertained from national registers. In 2000, RAND-36 questionnaire was sent to all survivors (n = 2251) and 1820 (80.9%) responded. The results of RAND scores were compared between baseline cholesterol groups, adjusted for age, baseline BMI, and smoking. Results: There was a strong and graded relationship between cholesterol divided by 1 mmol/L and total mortality: the men with cholesterol <4 mmol/L in baseline had the lowest mortality. Conversely, age-adjusted life-years gained decreased consistently with increasing baseline cholesterol, so that there was a mean 5.5 year difference between the lowest and highest baseline cholesterol group. The mean values in RAND-36 scores were systematically best among those with lowest cholesterol in midlife, but the global difference between cholesterol groups was significant only in physical functioning (p = 0.03). Conclusions: Low cholesterol value in midlife not only predicts better survival in old age; it is also associated with better HRQoL in old age.
Atherosclerosis Supplements, 2009
European Journal of Preventive Cardiology, 2012
Cardiovascular disease (CVD) is characterized by slow progressive atherosclerosis and arterial th... more Cardiovascular disease (CVD) is characterized by slow progressive atherosclerosis and arterial thrombotic events, leading to occlusions. Whether either of these presentations is more likely in patients with a genetic predisposition for CVD is still unknown. We suggest that a genetic predisposition for CVD is related to recurrent events of the same nature. We retrospectively investigated 275 patients with premature CVD and divided them in two groups according to their first event: an arterial thrombotic event or stable atherosclerosis. We used a Cox proportional-hazards model to estimate the effect of a positive family history for CVD on recurrent events of the same nature. This was tested in the entire cohort and in patients with coronary artery disease only. Patients with a first arterial thrombotic event and a positive family history had a threefold increased risk for a recurrent event of the same nature, compared to patients with a negative family history (hazard ratio 3.00, 95% confidence interval 1.32-6.81); p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). In contrast, a positive family history was not associated with an increased risk for a recurrent stable atherosclerosis (hazard ratio 0.98 (95% confidence interval 0.59-1.63). These findings were similar analysing the patients with coronary artery disease only. Additional adjustments for other risk factors did not change these associations. Patients with a first premature arterial thrombotic event and a positive family history for CVD have an increased risk for a second event of the same nature. This might be due to unknown hereditary mechanisms leading to recurrent acute events.
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Papers by sara-joan pinto