Anjali Basu

Calcutta University, Human Physiology, Department Member

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Phone: 9836015747
Address: 12B Simlai Para Bye Lane. Paikpara. Kolkata- 700002. West Bengal. India

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Elina Mitra

University of Calcutta

sanatan mishra

JPR Solutions

mahgoub Mustafa

National Organisation For Drug Control And Research( Nodcar )

Calcutta University

Parul university

Mansoura University

Govt of West Bengal

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Papers by Anjali Basu

Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats

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BENEFICIAL ROLE OF MELATONIN IN THE COMPLETE RECOVERY FROM ISOPROTERENOL- INDUCED CARDIAC INJURY IN RATS

Objective: The objective of the present study was to determine the efficacy of the pineal hormone... more

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Mukherjee D 2010-JPR

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Protective effect of aqueous garlic extract against lead-induced hepatic injury in rats

Effect of aqueous extract of garlic on hepatic injury due to lead-induced oxidative stress in exp... more Effect of aqueous extract of garlic on hepatic injury due to lead-induced oxidative stress in experimental rats has been investigated. Lead acetate (LA) at a dose of 15 mg / kg body wt was administered ip to rats for 7 consecutive days to induce hepatic injury. Freshly prepared aqueous garlic extract (AGE) at a dose of 50 mg /kg body wt was fed orally to rats 1 h before LA treatment for similar period. LA treatment caused hepatic injury as evident from increased activities of serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP), increased serum bilirubin level and damage in the tissue morphology. Lead-induced oxidative stress in liver was evident from increased levels of lipid peroxidation and reduced glutathione. The decreased activity of superoxide dismutase (SOD) and an increased activity of catalase as well as an increased activity of xanthine oxidase (XO) indicate generation and possible accumulation of reactive oxygen intermediates. Furthermore, altered activities of lactate dehydrogenase (LDH), isocitrate dehydrogenase (ICDH), alpha-keto glutarate dehydrogenase (α-KGDH) and succinate dehydrogenase (SDH) also indicate an impaired substrate utilization and generation of oxidative stress. All these changes were found to be mitigated when the rats were pre-treated with the AGE. Results indicate that AGE has the potential to ameliorate lead-induced hepatic injury due to oxidative stress in rats. The protective effects may be due to the antioxidant properties of AGE and may have future therapeutic relevance.

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Basu A 2013-JCTR (Issue 3)

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Dutta S 2013-AJPCR

Objectives: The present study is aimed at investigating the involvement of oxidative stress in is... more Objectives: The present study is aimed at investigating the involvement of oxidative stress in ischemic heart disease (IHD) of patients in tertiary care hospital in Kolkata. Methods: Serum parameters of myocardial injury, oxidative stress biomarkers and antioxidant enzymes were measured. These data were supported by the data of electrocardiography and echocardiography. Results: The current studies indicate involvement of oxidative stress in Indian IHD patients, and assessing these biomarkers may be useful in diagnosis of patients with ischemic hypertrophic cardiomyopathy. Conclusion: Cardiovascular diseases are becoming one of the leading health problems in India. The majority of cardiovascular diseases and related complications occur due to imbalance of oxidants and pro-oxidants in an individual. Thus, oxidative stress is one of the main factors in ischemic heart disease (IHD).

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Ghosh AK 2013-AJPCR

Cu 2+ -ascorbate induced oxidative stress in goat red blood cell-an established model of oxidativ... more Cu 2+ -ascorbate induced oxidative stress in goat red blood cell-an established model of oxidative stress in vitro was used for the present investigation. Terminalia arjuna (TA) an important medicinal plant has been found to be of therapeutic benefit in the treatment of cardiovascular diseases and reactive oxygen species (ROS) play a critical role in the pathogenesis of various cardiovascular diseases. The cardioprotective effects of TA are thought to be caused by the antioxidant nature of several of the constituents of TA extract. In a preliminary attempt to characterize the antioxidant properties of TA, our present studies indicate that aqueous TA bark extract is capable of protecting against oxidative stress as is evident from its effect on the biomarkers of oxidative stress, the antioxidant enzymes and the ROS scavenging activities. Aqueous TA bark extract decreased the level of lipid peroxidation, increased the reduced glutathione content and decreased the protein carbonyl content in Cu 2+ -ascorbate treated RBCs. The activities of antioxidant enzymes, catalase and superoxide dismutase (SOD), were also found to be protected by this aqueous bark extract. Aqueous bark extract of TA was found to scavenge hydroxyl radical in a chemically defined system. It also exhibited superoxide anion radical scavenging activity.

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AQUEOUS TULSI LEAF (OCIMUM SANCTUM L.) EXTRACT PROTECTS AGAINST PIROXICAM- INDUCED GASTRIC ULCERATION IN RATS: INVOLVEMENT OF ANTIOXIDANT MECHANISMS

The present studies were aimed at evaluating whether an aqueous extract of Tulsi leaves is capabl... more

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PROTECTIVE EFFECT OF AQUEOUS BARK EXTRACT OF TERMINALIA ARJUNA AGAINST COPPER- ASCORBATE INDUCED OXIDATIVE STRESS IN VITRO IN GOAT HEART MITOCHONDRIA

Objective: The present study is aimed at investigating the effect of aqueous bark extract of Term... more Objective: The present study is aimed at investigating the effect of aqueous bark extract of Terminalia arjuna (TA) against Cu +2 -ascorbate induced oxidative stress in goat heart mitochondria in vitro. Methods: Fresh goat heart mitochondria was prepared and oxidative stress was induced in vitro with Copper-ascorbate. Biomarkers of oxidative stress, activities of antioxidant enzymes, Kreb's cycle enzymes and respiratory chain enzymes were determined using standard methods. Results: Treatment of copper-ascorbate treated mitochondria with aqueous bark extract of TA increased reduced glutathione (GSH ) levels, reduced lipid peroxidation (LPO) levels and protein carbonyl (PCO) content. It also protects the activities of Mnsuperoxide dismutase (Mn-SOD), glutathione reductase (GR) and glutathione peroxidase (GPx) from being altered. Furthermore, it also restores the activities of pyruvate dehydrogenase (PDH), different Kreb's cycle enzymes and mitochondrial respiratory chain enzymes. Moreover, this extract also possesses antioxidant property as established by DPPH radical scavenging activity and reducing power.

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Basu A 2013-AJPCR

The effect of different doses of melatonin or aqueous Tulsi (Holy Basil) leaf homogenate (TLH) wa... more The effect of different doses of melatonin or aqueous Tulsi (Holy Basil) leaf homogenate (TLH) was studied against piroxicam-induced gastric ulceration in rats. Melatonin or TLH was found to protect the gastric mucosa individually following piroxicam treatment. Pre-treatment of rats with increasing doses of melatonin or TLH decreased the piroxicam-induced oxidative stress in the gastric tissue. Our studies also revealed that both melatonin (20 mg/kg BW i.p.) and TLH (100 mg/kg BW fed orally), individually, could not protect the gastric tissue from developing ulcers. However, when rats were pre-treated with melatonin and TLH in combination, at the doses at which neither was effective individually, the combined therapy completely prevented ulcers following piroxicam treatment. Melatonin and TLH in combination ameliorated the oxidative stress induced in the gastric tissue due to piroxicam by preventing the alterations in the bio-markers of oxidative stress and the activities and levels of antioxidant enzymes. The biochemical analyses were supported by macroscopic and microscopic studies of gastric tissue. Thus, the combination seems to work synergistically to reduce piroxicam-induced gastric damage in rats, strongly indicating that it may be a safe gastro-protective cotherapy especially, in situations where the use of anti-inflammatory drugs is the only choice.

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Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats

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BENEFICIAL ROLE OF MELATONIN IN THE COMPLETE RECOVERY FROM ISOPROTERENOL- INDUCED CARDIAC INJURY IN RATS

Objective: The objective of the present study was to determine the efficacy of the pineal hormone... more

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Mukherjee D 2010-JPR

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Protective effect of aqueous garlic extract against lead-induced hepatic injury in rats

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Basu A 2013-JCTR (Issue 3)

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