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SLC9A4

S Wikipedije, slobodne enciklopedije
(Preusmjereno sa SLC5A4)
SLC9A4
Identifikatori
AliasiSLC9A4
Vanjski ID-jeviOMIM: 600531 MGI: 105074 HomoloGene: 72232 GeneCards: SLC9A4
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za SLC9A4
Genomska lokacija za SLC9A4
Bend2q12.1Početak102,473,226 bp[1]
Kraj102,533,972 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za SLC9A4
Genomska lokacija za SLC9A4
Bend1 B|1 19.51 cMPočetak40,619,241 bp[2]
Kraj40,669,885 bp[2]
Ontologija gena
Molekularna funkcija solute:proton antiporter activity
antiporter activity
sodium:proton antiporter activity
potassium:proton antiporter activity
Ćelijska komponenta integral component of membrane
basolateral plasma membrane
apical plasma membrane
membrana
ćelijska membrana
Biološki proces gastric acid secretion
proton transmembrane transport
epithelial cell development
cation transport
ion transport
regulation of pH
sodium ion transport
regulation of intracellular pH
sodium ion import across plasma membrane
potassium ion transmembrane transport
transmembrane transport
anion transmembrane transport
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001011552

NM_177084

RefSeq (bjelančevina)

NP_001011552

NP_796058

Lokacija (UCSC)Chr 2: 102.47 – 102.53 MbChr 1: 40.62 – 40.67 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Niskofinitetni natrij-glukozni kotransporter, znan i kao natrij/glukoza kotransporter 3 (SGLT3) ili član 4 poriodice 5 rastvornih nosača (SLC5A4) jest protein koji je kod ljudi kodiran genom SLC5A4 sa hromosoma 2.[5][6][7] Funkcionira kao senzor šećera.

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 659 aminokiselina, a molekulska težina 72.456 Da.[8]

1020304050
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKT
NRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVT
FEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSL
FICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASV
IYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLT
ISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQR
CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSE
CVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNS
ASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNG
QLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRM
ITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKP
IPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLK
KAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAV
VVFIHGYYA

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180251 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026065 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
  6. ^ Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (mart 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.
  7. ^ Jung H (oktobar 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.
  8. ^ "UniProt, Q9NY91" (jezik: engleski). Pristupljeno 19. 11. 2021.

Dpunska literatura

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Vnjski ninkovi

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Šablon:Porodica rastvornih nosača