S Wikipedije, slobodne enciklopedije
Protein 7 programirane ćelijske smrti je protein koji je kod ljudi kodiran genom PDCD7 .[ 5] [ 6]
Ovaj gen kodira protein slične sekvence mišjeg proteina koji je izvorno identificiran u embrionskim matičnim ćelijaka . U mišjim T-ćelijskim linijama ovaj protein povezan je sa glukokortikoidima i apoptotskim putevima izazvanim staurinom i povezan sa keramid omposredovanom signalizacijom. Ova zapažanja sugeriraju da je ovaj genski proizvod uključen u specifične apoptozne procese u T-ćelijama .[ 6]
Dužina polipeptidnog lanca je 485 aminokiselina , a molekulska težina 54.700 Da .[ 7]
10 20 30 40 50 MALPPFFGQG RPGPPPPQPP PPAPFGCPPP PLPSPAFPPP LPQRPGPFPG ASAPFLQPPL ALQPRASAEA SRGGGGAGAF YPVPPPPLPP PPPQCRPFPG TDAGERPRPP PPGPGPPWSP RWPEAPPPPA DVLGDAALQR LRDRQWLEAV FGTPRRAGCP VPQRTHAGPS LGEVRARLLR ALRLVRRLRG LSQALREAEA DGAAWVLLYS QTAPLRAELA ERLQPLTQAA YVGEARRRLE RVRRRRLRLR ERAREREAER EAEAARAVER EQEIDRWRVK CVQEVEEKKR EQELKAAADG VLSEVRKKQA DTKRMVDILR ALEKLRKLRK EAAARKGVCP PASADETFTH HLQRLRKLIK KRSELYEAEE RALRVMLEGE QEEERKRELE KKQRKEKEKI LLQKREIESK LFGDPDEFPL AHLLEPFRQY YLQAEHSLPA LIQIRHDWDQ YLVPSDHPKG NFVPQGWVLP PLPSNDIWAT AVKLH
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^ a b c GRCh38: Ensembl release 89: ENSG00000090470 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041837 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Park EJ, Kim JH, Seong RH, Kim CG, Park SD, Hong SH (Apr 1999). "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells" . Nucleic Acids Res . 27 (6): 1524–30. doi :10.1093/nar/27.6.1524 . PMC 148348 PMID 10037816 . ^ a b "Entrez Gene: PDCD7 programmed cell death 7" .^ "UniProt, Q8N8D1" . Pristupljeno 16. 7. 2021 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome" . RNA . 10 (6): 929–41. doi :10.1261/rna.7320604 . PMC 1370585 PMID 15146077 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
PDCD7 UCSC Genome Browser .
