New emerging membrane technologies can be used to produce micro- and nanoparticulates with a defi... more New emerging membrane technologies can be used to produce micro- and nanoparticulates with a defined particle size and narrow size distributions. These new technologies will lead to enhanced product formulation performance through improved product quality.
Characteristic features of fine particle aggregates, such as aggregate sizes and densities, are s... more Characteristic features of fine particle aggregates, such as aggregate sizes and densities, are strongly influenced by the detailed nature of the particle-particle interactions in that system. The features of these aggregates will, in turn, influence the properties of a settled bed of these aggregates, such as the shear yield strength and compressibility. Here, we discuss how measurements of individual particle-particle
Changes in the macroscopic nature of aqueous or colloidal formulations can lead to changes in the... more Changes in the macroscopic nature of aqueous or colloidal formulations can lead to changes in the odor, appearance or feel of a product. Data presented in this article demonstrates ultrasound scanning to determine formulation shelf life and monitor product quality.
Characteristic features of fine particle aggregates, such as aggregate sizes and densities, are s... more Characteristic features of fine particle aggregates, such as aggregate sizes and densities, are strongly influenced by the detailed nature of the particle-particle interactions in that system. The features of these aggregates will, in turn, influence the properties of a settled bed of these aggregates, such as the shear yield strength and compressibility. Here, we discuss how measurements of individual particle-particle
Supercritical fluids have been applied for many years for the separation of solutes from solids o... more Supercritical fluids have been applied for many years for the separation of solutes from solids or solute mixtures in both exploratory and industrial applications. In the pharmaceutical industry the generation of pure solid states without impurities is important as the presence of impurities can result in a change in chemical properties or lead to physical instability. The literature on the separation and purification of solutes from solid matrices and solute mixtures using supercritical fluids, with the main emphasis on pharmaceutically important molecules, is reviewed in this article. Also discussed is the application of supercritical fluids in the control of process impurities such as chemical intermediates and residual solvent and in polymorphic control and chiral resolution. As the generation of organic molecules of pharmaceutical interest with high purity is important in pharmaceuticals this review additionally provides a brief overview of highly selective chemical reactions in supercritical fluids.
New emerging membrane technologies can be used to produce micro- and nanoparticulates with a defi... more New emerging membrane technologies can be used to produce micro- and nanoparticulates with a defined particle size and narrow size distributions. These new technologies will lead to enhanced product formulation performance through improved product quality.
New emerging membrane technologies can be used to produce micro- and nanoparticulates with a defi... more New emerging membrane technologies can be used to produce micro- and nanoparticulates with a defined particle size and narrow size distributions. These new technologies will lead to enhanced product formulation performance through improved product quality.
Characteristic features of fine particle aggregates, such as aggregate sizes and densities, are s... more Characteristic features of fine particle aggregates, such as aggregate sizes and densities, are strongly influenced by the detailed nature of the particle-particle interactions in that system. The features of these aggregates will, in turn, influence the properties of a settled bed of these aggregates, such as the shear yield strength and compressibility. Here, we discuss how measurements of individual particle-particle
Changes in the macroscopic nature of aqueous or colloidal formulations can lead to changes in the... more Changes in the macroscopic nature of aqueous or colloidal formulations can lead to changes in the odor, appearance or feel of a product. Data presented in this article demonstrates ultrasound scanning to determine formulation shelf life and monitor product quality.
Characteristic features of fine particle aggregates, such as aggregate sizes and densities, are s... more Characteristic features of fine particle aggregates, such as aggregate sizes and densities, are strongly influenced by the detailed nature of the particle-particle interactions in that system. The features of these aggregates will, in turn, influence the properties of a settled bed of these aggregates, such as the shear yield strength and compressibility. Here, we discuss how measurements of individual particle-particle
Supercritical fluids have been applied for many years for the separation of solutes from solids o... more Supercritical fluids have been applied for many years for the separation of solutes from solids or solute mixtures in both exploratory and industrial applications. In the pharmaceutical industry the generation of pure solid states without impurities is important as the presence of impurities can result in a change in chemical properties or lead to physical instability. The literature on the separation and purification of solutes from solid matrices and solute mixtures using supercritical fluids, with the main emphasis on pharmaceutically important molecules, is reviewed in this article. Also discussed is the application of supercritical fluids in the control of process impurities such as chemical intermediates and residual solvent and in polymorphic control and chiral resolution. As the generation of organic molecules of pharmaceutical interest with high purity is important in pharmaceuticals this review additionally provides a brief overview of highly selective chemical reactions in supercritical fluids.
New emerging membrane technologies can be used to produce micro- and nanoparticulates with a defi... more New emerging membrane technologies can be used to produce micro- and nanoparticulates with a defined particle size and narrow size distributions. These new technologies will lead to enhanced product formulation performance through improved product quality.
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Papers by Lyn Daintree