Saeid Safari

ANZCA, Mercy Hospital For Women, Anaesthetic Fellow

Shahid Beheshti University of Medical Sciences, Functional Neurosurgery Research Center (FNRC), Faculty Member

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Anesthesiologist, Editorial Manager, Medical Journalist
Assistant Professor (Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence)

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Caroline Smet-Nocca

Université de Lille

Frida Kleiman

Krzysztof Nieznanski

Nencki Institute of Experimental Biology

Joanna Chiu

University of California, Davis

Tiago F Outeiro

University of Göttingen Medical Centre

Faidon Brotzakis

muge serhatli

TUBITAK

Anna Mietelska-porowska

Anna Mietelska

karunya ramani

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Papers by Saeid Safari

Structural Analysis and Conformational Dynamics of Short Helical Hyperphosphorylated Segments of Tau Protein (Sequence 254–290) in Alzheimer’s Disease: A Molecular Dynamics Simulation Study

Frontiers in Molecular Biosciences, Aug 8, 2022

Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose early diagnosis leads ... more Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose early diagnosis leads to a chance for successful treatment and decreases the side effects. Hyperphosphorylation of tau proteins is a pathological hallmark of AD that causes it to lose its attachment ability to the microtubules. Alteration of tau structure due to its hyperphosphorylation is an exciting challenge regarding AD treatments. Here, we aimed to examine the structural alterations of short helical segments of tau protein with one to three phosphorylated sites by molecular dynamics simulation. Results indicated that the interaction of two similar segments with three phosphorylated sites (P-Ser262, 285, and 289) formed a compact and more stable structure than the one phosphorylated site complex (P-Ser262). Moreover, due to the high dynamics of the P-Ser262 complex, several structures were made with different conformational dynamics, but there was only one stable cluster of the P-Ser262, 285, and 289 complex during simulation. It seems that the P-Ser262, 285, and 289 complex plays an important role in the formation of paired helical filaments (PHFs) by forming a stable dimer. Generally, it is important to identify how structural features of segments in tau protein change when the phosphorylated sites increase from one to three sites and their effects on the formation of PHFs for drug design and diagnostic biomarkers.

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Tricalcium Phosphate Containing Sodium Hexametaphosphate as Polymer Suspension Stabilizer

علوم و تکنولوژی پلیمر, 2008

Tricalcium phosphate as hydroxyapatite is used as a suspension stabilizer in styrene polymerizati... more Tricalcium phosphate as hydroxyapatite is used as a suspension stabilizer in styrene polymerization process. Particle size of TCP plays an essential role in the particles' size distribution and geometrical form of polystyrene products. As the particle size of TCP is reduced, there will be much better chance to engulf the styrene particles. The higher the number of TCP particles surrounding each styrene particle, the lesser will be their tendency to form a large particle after collision. Therefore, there will be higher percentages of spherical polystyrene with small particle size and narrower size distribution in the product. Experimental results have indicated that the addition of sodium hexametaphosphate (SHMP) to the reaction mixture of lime and phosphoric acid, after drying the product by spray dryer, lead to decrease the size of TCP particles from ca. 5 μm (without SHMP) to ca. 1.5 μm (with SHMP). In this study, the role of TCP containing SHMP as polymer suspension stabilize...

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Implication for health policy/practice/research/medical education: Oxycodone, an analgesic opioid... more Implication for health policy/practice/research/medical education: Oxycodone, an analgesic opioid, is used for many types of pain, and is especially useful for severe and acute pain. The aim of this article is to highlight findings relating to the use of oxycodone in the field of pain management. Oxycodone is an analgesic opioid medication that is gen-erally used for the relief of moderate-to-severe pain. It was first developed by German researchers in 1916 from opium-derived thebaine (1). Oxycontin was approved by the FDA in 1995, and was introduced into the United States market in 1996 (2). By 2001 it was the best-selling narcotic pain reliever in the United States, and in 2008 sales in the United States reached $2.5 billion (3). Oxycodone is metabolized by the cytochrome p450 en-zyme system in the liver. Only 10 % is excreted unchanged in urine (4, 5). Because it is metabolized by CYP3A4 and CYP2D6 enzymes, oxycodone is prone to pharmacoki-

Correction to: Parkinson’s disease and COVID‑19: a systematic review and meta‑analysis

Neurological Sciences, 2021

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$Research paper thumbnail of Local Anesthetic Systemic Toxicity Following Infraclavicular Nerve Block Under Ultrasound Guidance$

Local Anesthetic Systemic Toxicity Following Infraclavicular Nerve Block Under Ultrasound Guidance

Investigating the Relationship Between Mother-Child Bonding and Maternal Mental Health

Journal of Comprehensive Pediatrics, 2018

Background: Mother-child bonding is rooted in the affective relationship between mother and child... more Background: Mother-child bonding is rooted in the affective relationship between mother and child that is shaped during pregnancy and leads to the mental growth of infants. Objectives: This study was conducted to determine the relationship between mother-child bonding and maternal mental health in Ilam. Methods: In this descriptive-analytical study, 300 mothers in Ilam were selected using a two-stage cluster sampling method. The demographic characteristics questionnaire, the mother-infant bonding scale, Spielberger anxiety inventory, and edinburgh postnatal depression scale constituted the data collection instruments in this study, which were completed in the eighth to tenth postnatal week. Data were analyzed in SPSS via descriptive statistics (means and standard deviations) and inferential tests (t tests and ANOVA). Results: The results of this study revealed that the mean and standard deviation of the obtained mother-child bonding scores were 38.48 ± 12.86. Weakened mother-child bonding and risk of child abuse comprised the highest and lowest frequencies, respectively. Mother-child bonding had a statistically significant association with mothers' state anxiety, trait anxiety, and depression, and these variables affected mother-child bonding (P < 0.05). Conclusions: Considering the relationship between mother-child bonding and maternal mental health, proper screening is required to pursue secondary prevention in pregnant mothers. In addition, it is essential to perform necessary interventions to improve maternal mental health to facilitate better mother-child bonding.

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The Comparison of Perinatal Outcomes in Early Delivery Versus Postdate Labor

Journal of Comprehensive Pediatrics, 2017

Background: Prenatal mortality and morbidity increase after 40 weeks of gestation. The current st... more Background: Prenatal mortality and morbidity increase after 40 weeks of gestation. The current study aimed at comparing maternal and neonatal outcomes between term and postterm pregnancies. Methods: The current prospective cohort study was performed on 1180 singleton, cephalic fetus, and uncomplicated pregnancy cases admitted for labor. Pregnant mothers were divided into 3 groups. Group 1 included 750 cases in 38 to 40 weeks, group 2 included 250 cases in 40 to 41 weeks, and group 3 included 180 cases in over 41 weeks of gestation. Prenatal outcomes were recorded as: fetal distress, meconium passage, meconium aspiration, fetal weight ≥ 4 kg, Apgar score in 1 and 5 minutes, neonatal intensive care unit (NICU) admission, maternal infection, postpartum hemorrhage, and the rate of cesarean section. Results: There were significant differences in the rate of fetal distress (P < 0.001), meconium passage (P = 0.001), meconium aspiration syndrome (P < 0.001), Apgar score ≤ 3 at 1 (P = 0.025) and 5 minutes (P < 0.001), admission to NICU (P < 0.001), rate of cesarean section (P < 0.001), and maternal infection (P = 0.001) among the groups. The frequency of fetal distress was lower in group1 compared with group 2 (1.6% versus 4.4%; P = 0.011). Also fetal distress was significantly lower in group 1 than group 3 (1.6% versus 10.9%; P < 0.001). The meconium passage and meconium aspiration syndrome were statistically lower in group 1 compared with group 2 (1.6% versus 8%; P < 0.001 for meconium passage, and 0.9% versus 5.6%; P < 0.001 for meconium aspiration syndrome). Also meconium passage and meconium aspiration syndrome were significantly lower in group 1 compared with group 3 (1.6% versus 13.9%; P < 0.001 for meconium passage, and 0.9% versus 10%; P < 0.001 for meconium aspiration syndrome). The cesarean section was more frequent in group 2 compared with group 1 (24.8% versus 13.6%; P < 0.001) and in group 3 compared with group 1 (33.3% versus 13.6%, P < 0.001). There was no significant difference in the mean fetal weight, fetal weight ≥ 4 kg, and postpartum hemorrhage in females between the 3 groups. Conclusions: Late-term and postterm births are associated with higher rates of fetal and neonatal morbidity and maternal risks compared to pregnancy termination before 40 weeks of gestation, and earlier birth induction is recommended in such cases.

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Abstract PR504

Anesthesia & Analgesia, 2016

Halothane: How should it be treated in a developing country?

Paper: NUMERICAL ANALYSIS OF SECOND ORDER WAVE DIFFRACTION ON TWO-DIMENSIONAL BODIES

Paper: AN IMPROVED NUMERICAL ALGORITHM TO SIMULATE THE INTERACTION OF NONLINEAR WATER WAVES WITH A FIXED LARGE CYLINDER

Paper: EFFECT OF ORAL PREGABALIN PREMEDICATION ON POST-OPERATIVE PAIN IN LAPAROSCOPIC GASTRIC BYPASS SURGERY

Paper: EFFECTS OF SINGLE-DOSE PREGABALIN ON POSTOPERATIVE PAIN IN DACRYOCYSTORHINOSTOMY SURGERY

Paper: THE RELATIONSHIP BETWEEN SOCIAL LINK ESTABLISHED BY FAMILY AND INTERPERSONAL VIOLENCE OF MALE JUVENILES IN YAZD

Paper: AN ANTHROPOLOGICAL STUDY ON ARIA VARNA AND DASA VARNA SOCIAL CLASSES IN THE RIG-VEDIC

$Research paper thumbnail of Numerical Analysis of Second Order Wave Diffraction on Two-Dimensional Bodies$

Numerical Analysis of Second Order Wave Diffraction on Two-Dimensional Bodies

An improved numerical algorithm to simulate the interaction of nonlinear water waves with a fixed large cylinder

An Anthropological Study on Aria Varna and Dasa Varna Social Classes in the Rig-Vedic

Pain management in intensive care unit patients: the role of ultra-short acting opioid: remifentanil

Anesthesiology and pain medicine, 2013

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The role of non-steroidal anti-inflammatory drugs in acute liver injury

BMJ, 1992

mortality of patienits with sinus iiodc disease: comparatiVe efficts of atrial and ventricular pa... more mortality of patienits with sinus iiodc disease: comparatiVe efficts of atrial and ventricular pacing. PACE 19(0;13:2076-C. 9 Rosenqv'ist MN, Obel I%X-. Atrial pacinig and the risk for AV block: is there a time for changc in attitude? IPAzCE 1989;12:97-1l01. I0 Schuller H, Brandt J. 'I'he pacemaker syndrome: old and iiew causes.

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Structural Analysis and Conformational Dynamics of Short Helical Hyperphosphorylated Segments of Tau Protein (Sequence 254–290) in Alzheimer’s Disease: A Molecular Dynamics Simulation Study

Frontiers in Molecular Biosciences, Aug 8, 2022

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Tricalcium Phosphate Containing Sodium Hexametaphosphate as Polymer Suspension Stabilizer

علوم و تکنولوژی پلیمر, 2008

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