Papers by Fereshteh Dardmeh
Human Reproduction, Jul 1, 2020
1. Agarwal et al., 2008] Agarwal, A., Deepinder, F., Cocuzza, M., Short, R. A., and Evenson, D. P... more 1. Agarwal et al., 2008] Agarwal, A., Deepinder, F., Cocuzza, M., Short, R. A., and Evenson, D. P. (2008)., Efect of vaginal lubricants on sperm motility and chromatin integrity: a prospective comparative study.Fertility and sterility, 89(2):375. 2. American Society for Reproductive Medicine, 2008] American Society for Reproductive Medicine (2008). Optimizing natural fertility. Fertility and sterility, 90(5):1. 3. [Fernandez et al., 2005] Fernandez, J. L., Muriel, L., Goyanes, V., Segrelles, E., Goslvez, J., Enciso, M., LaFromboise, M., and Jonge, C. D. (2005). Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test. Fertility and sterility, 84(4):833-842 4. Mowat, A., Newton, C., Boothroyd, C., Demmers, K., & Fleming, S. (2014). The effects of vaginal lubricants on sperm function: an in vitro analysis. Journal of Assisted Reproduction and Genetics, 31(3), 333–9. http://doi.org/10.1007/s10815-013-0168-x The results of this study indicat...
Journal of Veterinary Pharmacology and Therapeutics, 2009
Acta Obstetricia et Gynecologica Scandinavica, 2021
Microbiome refers to the collective genomes of the microorganisms in a particular environment, an... more Microbiome refers to the collective genomes of the microorganisms in a particular environment, and microbiota is the community of microorganisms themselves. Approximately 100 trillion microorganisms exist in the human gastrointestinal tract, and the microbiome is now best thought of as a virtual organ of the body. The human genome consists of about 23 000 genes, but the microbiome encodes over 3 million genes producing thousands of metabolites, which replace many of the functions of the host, consequently influencing the host’s fitness, phenotype, and health. Some studies also strongly suggest that gut microbiota contributes to complications related to highfat diet feeding and metabolic disorders. Probiotics are live microorganisms that supposedly have health benefits when consumed. For humans, they can be found in yogurt and other fermented foods or as dietary supplements. Different advantages of probiotic supplements have previously been reported. In recent years, the healthpromot...
Iranian Journal of Veterinary Medicine, 2008
The Liquorice Plant Extract (LPE) has been used traditionally in the world for various therapeuti... more The Liquorice Plant Extract (LPE) has been used traditionally in the world for various therapeutic purposes. LPE are extensively used in gastric ulcer, anticancer, inflammation and allergy. The hepatotoxic effect of carbon tetrachloride is due to the oxidative damage by free radical production, and antioxidant property is thought to be one of the approaches of hepatoprotective therapeutic agents. Moreover, CCL4-induced hepatoxicity could be used as a model for plenty of water contamination including chlorinated hydrocarbons. Therefore, we aimed to evaluate the antioxidant effect of LPE CCl4-induced hepatotoxicity in fish. Fresh roots of LP were air-dried; powdered and ethanolic extract was prepared using suxhlet. The hepatoprotective study was carried out in Common Carp (Cyprinus Carpio) weighing (30-50g). Thirty nine fishes were equally divided into 5 groups (n = 3 in each group). Group I (control) and group II were given DMSO and CCl4 respectively, for 45 minutes. CCL4 was adminis...
The examination of semen is generally performed in accordance with the World Health Organization ... more The examination of semen is generally performed in accordance with the World Health Organization (WHO) “laboratory manual for examination and processing of human semen” manually (subjective), or using CASA computer aided sperm analysis systems (objective). The Sperm Class s Analyzer (SCA) CASA system assesses various detailed motion and velocity parameters, which are not possible in the subjective method and can give indications of kinematic properties like speed, direction and straightness as biomarkers of sperm fertility potential. To maximize the likelihood of success in Assisted reproductive technology (ART), semen parameters such as volume, spermatozoa concentration and motility are expected to be within normal limits classified by the WHO. Several factors have shown to have an influence on semen quality parameters, one of which is the length of sexual abstinence before sample collection. The mentioned WHO (2010) guideline has suggested that a 2-7 days abstinence time before sa...
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2021
OBJECTIVE Metabolomic profiling of seminal plasma has been suggested as a possible approach for a... more OBJECTIVE Metabolomic profiling of seminal plasma has been suggested as a possible approach for a fast and non-invasive male infertility evaluation diagnosis. However, metabolomics profiles in normozoospermic men have not been thoroughly investigated, and the influence of ejaculation-abstinence has not been described. To provide interim reference values and find associations between the metabolomics profiles of human seminal plasma and length of ejaculation-abstinence period in normozoospermic men. STUDY DESIGN Semen samples collected after long (4-7 days) and short abstinence (2 h) from 31 normozoospermic males were assessed for routine quality parameters before the seminal plasma was separated by centrifugation. Metabolomics profiles of the seminal plasma were then determined using untargeted Nuclear Magnetic Resonance Spectroscopy. RESULTS In total, 30 metabolites were identified. Pyruvate showed a higher concentration, while fructose, acetate, choline, methanol, N-acetylglucosamine, O-acetylcarnitine, uridine, and sn-glycero-3-phosphocoline showed lower concentrations in samples collected after short abstinence (vs. long). All metabolites showed lower absolute amounts (volume × concentration) following shorter abstinence. However, the lower sperm concentration in samples collected after short abstinence resulted in higher absolute amounts of pyruvate and taurine per spermatozoa: pyruvate 1.92 (1.12-3.87) vs. 1.29 (0.83-2.62) (P < 0.001) and taurine 0.58 (0.36-0.92) vs. 0.43 (0.28-0.95) (P < 0.05) ng/106 spermatozoa. Simultaneously, there was a higher percentage of progressively motile spermatozoa in samples collected after the short abstinence. CONCLUSION The generally lower concentrations of seminal metabolites after short abstinence periods may be related to the shorter time available for secretion and collection of these metabolites by the accessory glands and the epididymides. The concomitant lower number of spermatozoa in the second ejaculate resulted in increased absolute amounts of pyruvate and taurine per spermatozoa, accompanied by increased spermatozoa motility in these samples. The simultaneous increase in percentages of motile spermatozoa and absolute amounts of pyruvate and taurine per spermatozoa after shorter abstinence might indicate that these two metabolites play a more critical role in sperm motility, which should be further investigated in future studies.
PloS one, 2017
Probiotics have been proposed as alternatives to pharmacological products in several medical cond... more Probiotics have been proposed as alternatives to pharmacological products in several medical conditions including the modulation of obesity, which is frequently associated with poor semen quality. However, effects of probiotics on male fertility have been less investigated. This study assessed the effect of Lactobacillus rhamnosus PB01 (DSM-14870) on sperm kinematic parameters in Normal-weight (NW) and diet-induced obese (DIO) models. NW and DIO C57BL/6NTac mice were divided into two subgroups with or without a single daily dose (1x109CFU) of L. rhamnosus for four weeks. Sperm motility and kinematics together with blood lipid profiles and reproductive hormone levels were assessed using the sperm class analyzer system. Probiotic supplementation increased serum testosterone, LH and FSH levels in both NW and DIO groups resulting in significantly (P<0.05) higher velocity (VSL, VCL and VAP) and percentages of progressively motile sperm and significantly lower percentages of immotile s...
Scandinavian Journal of Pain, 2017
Aims The association between low fertility potential and an overweight is well recognized. In add... more Aims The association between low fertility potential and an overweight is well recognized. In addition, a link between pain and overweight condition has been identified. However, it is not known whether overweight pain patients present any alterations in fertility potentials. Hence, the current study provided a profounder vision into the possible relation between an overweight condition, chronic musculoskeletal pain, and fertility potential in overweight male patients. Methods This “observational study” was based on 10 overweight chronic pain patients (OP and 10 healthy matched controls (OC) from the referrals to the orthopedic department at Aalborg University Hospital, Aalborg, Denmark. The study was approved by the regional Ethics Committee of the Northern Jutland, Denmark and conducted from June 2014 to December 2015. Semen samples were obtained from all participants and assessed for sperm concentration, motility, and kinematic parameters with the Sperm Class Analyzer (SCA®, Spai...
Journal of Nanoscience and Nanotechnology, 2017
The incorporation of metal sulfide mixture, manganese sulfide and zinc sulfide (MnS–ZnS) or manga... more The incorporation of metal sulfide mixture, manganese sulfide and zinc sulfide (MnS–ZnS) or manganese sulfide and cadmium sulfide (MnS–CdS), in two types of montmorillonites (sodium montmorillonite and cetyltrimethylammonium modified montmorillonite) was investigated. The hybrids were characterized by powder X-ray diffraction, thermogravimetric-differential thermal analysis, transmission electron microscopy (TEM), and Raman, UV-visible and photoluminescence spectroscopies. The experimental evidences such as the expansion of the interlayer spaces and the presence of the absorption and photoluminescence due to MnS, ZnS and/or CdS revealed that the mixed metal sulfides formed in the interlayer space of montmorillonites. TEM images of the hybrids showed diskor plate-shaped nanoparticles with a mean diameter of ca. 2 nm. The increase of the luminescence intensities of the hybrids was assumed to be caused by quantum confinement effect in the interlayer space of montmorillonite.
Background and Aims: Pain thresholds or responsiveness to painful stimuli has been demonstrated t... more Background and Aims: Pain thresholds or responsiveness to painful stimuli has been demonstrated to be affected by body conditions such as obesity. Generally, a lower pain threshold has been demonstrated in obesity both in animals and humans. Among the endogenous factors influencing the obesity, intestinal microbiota has also been suggested to influence the pain sensitivity. However, the effect of oral probiotics on pain has not been studied systematically. This study examined the effect of oral probiotic (Lactobacillus Rhamnusus) on mechanical sensitivity in behaving diet-induced obese (DIO) mice. Methods: Six-week old male C57BL/6NTac mice were fed with a high fat diet (week 1-4) to produce DIO mice. The DIO mice were then randomly assigned to 2 groups treated with a single daily dose (1x109 CFU) of L. Rhamnusus (test group) or physiological saline (control group) for 4 weeks (weeks 5-8). Sensitivity to mechanical stimulation (hind-paw withdrawal), was assessed by the electronic Vo...
Scandinavian Journal of Pain, 2015
Aims Sex hormones play an important role in pain in many chronic pain conditions. Relationship be... more Aims Sex hormones play an important role in pain in many chronic pain conditions. Relationship between chronic pain and sperm quality has not been investigated thoroughly and may provide an insight to better understanding, management and treatment of cases where chronic pain and male sub-fertility co-exist. Methods Neat (fresh semen) and processed sperm from 15 males with orthopedic chronic pain (CP) were assessed and compared with 15 healthy age matched controls. Sperm analysis was performed using the SCA computer-aided sperm analyzer. Results There was no significant difference in any parameters of the neat semen between the pain and control group. However the percentage of non-progressive motile spermatozoa (type B) was significantly higher in the pain group (27.96) compared to the control group (15.96). Straight line trajectories including linearity, straightness, wobble and beat cross frequency were also significantly higher in the processed sample of the CP group. Conclusions ...
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Papers by Fereshteh Dardmeh